2,4-Difluoroaniline

I-CAS367-25-9

Iimpawu zeekhemikhali: into enamafutha emthubi ongacacanga.

Ukusetyenziswa: I-2,4-Difluoroaniline liyeza eliphakathi kwi-organic synthesis. Kwi-pharmaceuticals, lisetyenziswa kwi-difluorophenylsalicylic acid kunye ne-polyfluorodiphenyl acid. I-Difluorophenylsalicylic acid liyeza elingelona ele-carboxylic acid elichasene nokuvuvukala (NSAID), elinegama elingelona ele-international nonproprietary name (INN) Diflunisal. Eli chiza litsha le-salicylic acid, nangona lingenalo iqela le-acetyl le-aspirin, liqulathe iqela le-difluorophenyl, nto leyo ebangela ukuba kubekho iziphumo ebezingalindelekanga ezimbalwa ze-antiplatelet, ukusabela okuncinci kwesisu, kunye nobude bexesha lokusebenza obuhlala iiyure ezi-8-12. Lisenokuba lelona yeza le-salicylic acid lithembisayo. Likwaliyeza eliphakathi elibalulekileyo kwimveliso yezibulali-zinambuzane.

Ifomula yemolekyuli C6H5F2N,

ubunzima bemolekyuli 129.11,

Inombolo ye-EINECS 206-687-5

Iqondo lokunyibilika -7.5 °C (elikhanyayo)

Iqondo lokubila 170 °C/753 mmHg (elikhanyayo)

Ubuninzi be-1.268 g/mL kwi-25 °C (elithayo)

Isalathisi sokuhombisa n20/D 1.506 (lit.)

Incopho yokutshaza 145 °F

Indlela yokuvelisa 1. Indlela yokunciphisa i-2,4-Difluoronitrobenzene: Umgubo wentsimbi kunye nesisombululo samanzi se-ammonium chloride zongezwa kwi-reduction reactor, zifudunyezwe ukuze ziphinde zibuyele kwi-reflux, emva koko i-2,4-difluoronitrobenzene yongezwa ngokuhla. Emva kokuba ukongeza kugqityiwe, phinda ubuyele kwi-reflux iiyure ezi-2. Emva kokuba ukusabela kugqityiwe, imveliso iyahlanjululwa ngomphunga, yahlulwe yiChemicalbook, kwaye yomiswe nge-calcium chloride ukuze kufunyanwe imveliso efanelekileyo ene-87%. 2. Ifunyenwe kwi-1,2,4-trichlorobenzene nge-nitration, i-fluorination, kunye ne-reductive dechlorination; okanye ifunyenwe kwi-m-phenylenediamine nge-diazotization, substitution, nitration, kunye ne-reduction.

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