Ngokwembono yembali yophuhliso lweshishini leekhemikhali eliphakathi laseTshayina, emva kweminyaka ephantse ibe ngama-30 yophuhliso, iingcali zezonyango ziye zaphuhliswa zisuka kwisebe elincinci leshishini leekhemikhali zaya kwishishini elikhulayo elinexabiso lemveliso eliziibhiliyoni zeeyuan, kwaye ukhuphiswano lwalo kwimarike luye lwaba lubi kakhulu.

Kuyaqondakala ukuba kwinqanaba lokuqala lophuhliso lweshishini leemveliso zamayeza, ngenxa yotyalo-mali oluncinci kunye nezinga eliphezulu lembuyekezo, amashishini eemveliso zamayeza afuywe njengekhowa, ingakumbi eZhejiang, eTaizhou, eNanjing nakwezinye iindawo ezineemeko ezilungileyo zophuhliso lweemveliso zamayeza, uphuhliso lukhawuleza kakhulu.

Okwangoku, njengoko utshintsho lwendlela yokuthengisa amayeza, kunye nokuveliswa kwamayeza amatsha kwimarike kuncitshisiwe, ubunzima bophuhliso lwemveliso entsha kushishino lwamayeza luya lukhula, imveliso yendabuko iya isiba kukhuphiswano oluqatha ngakumbi, inzuzo kushishino lwamayeza iyancipha ngokukhawuleza, kwaye amachiza aphakathi aba yimfuneko yokucinga ngengxaki yokuba uphuhliso lweshishini luqhubeka njani.

Eli shishini likholelwa ukuba kunokwenzeka ukuba lizakhele inzuzo yalo yokukhuphisana kwiinkalo zobuchwepheshe, impembelelo kunye notshintsho, ukuze livelele kwimarike.

Ngokuphathelele iteknoloji, ibhekisa kakhulu ekuphuculeni iteknoloji nokonga iindleko. Kubikwa ukuba indlela yenkqubo ye-pharmaceutical intermediate inde, inyathelo lokuphendula likhulu, ukusetyenziswa kwe-solvent kukhulu, amandla okuphucula ubugcisa makhulu.

Umzekelo, izinto ezikrwada ezingabalulekanga kangako zingasetyenziswa endaweni yezinto ezikrwada ezixabisekileyo ngakumbi, ezifana ne-liquid bromide ekuvelisweni kwe-aminothioamidic acid kunye ne-ammonium thiocyanate ekuvelisweni endaweni ye-potassium thiocyanate (i-sodium).

Ukongeza, isinyibilikisi esinye singasetyenziselwa ukuthatha indawo yezinyibilikisi ezahlukeneyo kwinkqubo yokusabela, kwaye iialcohols ezenziwe kwi-hydrolysis yeemveliso ze-ester zinokufunyanwa.

Ngokuphathelele impembelelo, ngokuyintloko yenza iimveliso zayo ezikhethekileyo kwaye iphucula impembelelo yayo kushishino. Kuyaqondakala ukuba ngenxa yokhuphiswano olukhulu lokudibanisa imveliso kushishino lwamayeza oluphakathi lwaseTshayina, ukuba amashishini anokwenza iimveliso zawo eziluncedo, ngokuqinisekileyo aya kuba neenzuzo ezingaphezulu kwimarike.

Ngokuphathelele utshintsho, okwangoku, ngeemfuno ezingqongqo zokhuseleko lokusingqongileyo eTshayina, izixhobo zityekele kumashishini anexabiso eliphezulu, kwaye ngokunyuka kweendleko zokhuseleko lokusingqongileyo, utshintsho lube yingxaki ekufuneka iqwalaselwe kuphuhliso oluzinzileyo lwamashishini aphakathi kwamayeza.

Kucetyiswa ukuba amashishini aphakathi kwamayeza afanele andise uthotho lwemizi-mveliso ukusuka phezulu ukuya ezantsi, aze aguqule izinto eziphambili abazisebenzisayo zibe yimveliso yawo. Ngale ndlela, iindleko zinokuncitshiswa ngakumbi, kwaye kwezinye izinto ezikhethekileyo, ukuzimela kwezixhobo eziphambili kunokuthintelwa.

Eli shishini lithi ukunyuka kokwehla, apho izinto ezidityanisiweyo zamayeza zenziwa ngqo kwi-apis, kunokunyusa ixabiso elongezelelweyo leemveliso ngelixa zithengiswa ngqo kwiinkampani zamayeza. Kubalulekile ukuqaphela ukuba kukho utyalo-mali olukhulu kulwandiso olusezantsi, kunye nemfuneko ephezulu yetekhnoloji yemveliso kunye nobudlelwane obuhle nabasebenzisi be-API. Ngokubanzi, amashishini aphambili aya kufumana iingenelo ezikhuphisanayo ngakumbi.

Ukongeza, UPHANDO nophuhliso lubaluleke kakhulu kushishino oluphakathi. Okwangoku, ishishini eliphakathi lezemithi laseTshayina ngokubanzi alinikeli ngqalelo ingako kuphando nophuhliso. Ke ngoko, kwimeko yokuphucula rhoqo iimfuno zobugcisa, amashishini e-R&D asebenzayo anamandla e-R&D aqinileyo aya kuqala, ngelixa amashishini amancinci naphakathi angenawo amandla e-r&d anokususwa yimarike. Kwixesha elizayo, ukugxila kushishino kuya kuphucuka ngakumbi kwaye inqanaba lophuhliso eliphakathi neliphantsi liya kuphuhliswa liye kwinqanaba eliphezulu.